Krzysztof Palczewski Selected Research

Retinal Diseases

1/2022	In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope.
1/2021	Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing.
11/2020	Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing.
5/2019	Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention.
1/2018	Two-photon imaging of the mammalian retina with ultrafast pulsing laser.
1/2018	Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs.
11/2017	Context-dependent compensation among phosphatidylserine-recognition receptors.
3/2017	Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser.
1/2017	Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa.
1/2017	Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue.

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Krzysztof Palczewski Research Topics

Disease

40	Retinal Degeneration 01/2021 - 11/2002
20	Macular Degeneration (Age-Related Maculopathy) 10/2018 - 10/2009
19	Retinitis Pigmentosa (Pigmentary Retinopathy) 05/2022 - 04/2003
19	Retinal Diseases 01/2022 - 01/2007
18	Blindness (Hysterical Blindness) 05/2022 - 05/2002
12	Stargardt Disease 10/2021 - 08/2011
10	Leber Congenital Amaurosis 01/2018 - 04/2004
6	Diabetic Retinopathy (Retinopathy, Diabetic) 11/2021 - 10/2013
6	Retinal Dystrophies 01/2021 - 04/2012
6	Neoplasms (Cancer) 01/2021 - 08/2002
4	Inflammation (Inflammations) 01/2022 - 04/2011
4	Photophobia (Light Sensitivity) 06/2021 - 05/2002
4	Vision Disorders (Hemeralopia) 01/2021 - 04/2004
4	Cone-Rod Dystrophies 04/2011 - 07/2007
3	Proteostasis Deficiencies 01/2022 - 01/2017
3	Night Blindness (Nyctalopia) 01/2022 - 10/2018
3	Vitamin A Deficiency 10/2014 - 07/2012
2	Atrophy 01/2022 - 09/2008
2	Inborn Genetic Diseases (Disease, Hereditary) 09/2021 - 01/2018
2	Eye Diseases (Eye Disease) 01/2020 - 06/2017
2	Geographic Atrophy 01/2017 - 08/2014
2	Phototoxic Dermatitis (Phototoxicity) 01/2017 - 07/2015
2	Usher Syndromes (Usher Syndrome) 01/2016 - 07/2009
2	Choroidal Neovascularization 10/2009 - 09/2008
2	Fundus Albipunctatus 10/2006 - 11/2002
1	Toxic Optic Neuropathy 01/2022
1	Osteitis Deformans (Paget's Disease of Bone) 01/2022
1	Frontotemporal Dementia (Semantic Dementia) 01/2022
1	Muscular Diseases (Myopathy) 01/2022
1	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia 01/2021
1	Thrombosis (Thrombus) 11/2020
1	Disease Progression 01/2020
1	Gliosis 01/2020
1	Ciliopathies 01/2020
1	Ganglion Cysts (Ganglion) 01/2020

Drug/Important Bio-Agent (IBA)

50	Retinaldehyde (Retinal)IBA 05/2022 - 05/2002
24	Proteins (Proteins, Gene)FDA Link 01/2020 - 04/2003
22	RetinoidsIBA 01/2021 - 11/2002
15	OpsinsIBA 01/2021 - 11/2002
10	Rhodopsin (Visual Purple)IBA 01/2020 - 05/2002
8	Vitamin A (Retinol)FDA LinkGeneric 01/2015 - 11/2002
7	retinylamineIBA 01/2021 - 12/2007
6	Pharmaceutical PreparationsIBA 01/2021 - 01/2007
5	Retinal Pigments (Pigments, Visual)IBA 01/2022 - 04/2008
5	9-cis-retinalIBA 09/2021 - 05/2002
5	EnzymesIBA 08/2014 - 07/2006
4	Rod OpsinsIBA 01/2018 - 01/2013
4	Retinyl EstersIBA 11/2017 - 05/2002
4	LipidsIBA 06/2017 - 06/2010
4	MicroRNAs (MicroRNA)IBA 01/2017 - 09/2011
3	lecithin-retinol acyltransferaseIBA 01/2015 - 06/2009
3	Carotenoids (Carotene)IBA 11/2013 - 03/2011
3	ATP-Binding Cassette Transporters (ABC Transporters)IBA 04/2012 - 01/2010
3	retinol dehydrogenaseIBA 04/2012 - 07/2007
2	CB-5083IBA 01/2022 - 01/2021
2	Valosin Containing ProteinIBA 01/2022 - 01/2021
2	retinol acetateIBA 09/2021 - 10/2009
2	Peptides (Polypeptides)IBA 01/2021 - 08/2002
2	Adenine FDA LinkGeneric 01/2021 - 11/2020
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2021 - 12/2014
2	A2-E (N-retinylidene-N-retinylethanolamine)IBA 01/2020 - 12/2007
2	retinal dimerIBA 01/2020 - 11/2009
2	LigandsIBA 10/2018 - 05/2013
2	c-Mer Tyrosine KinaseIBA 11/2017 - 12/2016
2	DNA (Deoxyribonucleic Acid)IBA 06/2017 - 09/2008
2	Schiff Bases (Schiff Base)IBA 07/2015 - 01/2014
2	AminesIBA 07/2015 - 12/2011
2	LipofuscinIBA 06/2015 - 09/2008
2	Triglycerides (Triacylglycerol)IBA 01/2015 - 07/2012
2	Membrane Proteins (Integral Membrane Proteins)IBA 04/2014 - 07/2009
2	Messenger RNA (mRNA)IBA 05/2013 - 09/2004
2	Phospholipids (Phosphatides)FDA LinkGeneric 07/2012 - 01/2012
2	TransferasesIBA 05/2010 - 07/2006
2	LecithinsIBA 05/2010 - 07/2006
2	retinoid isomerohydrolase (retinol isomerase)IBA 06/2009 - 09/2007
2	Oxidoreductases (Dehydrogenase)IBA 10/2006 - 11/2002
1	CytokinesIBA 01/2022
1	retinol dehydrogenase 5IBA 01/2022
1	Serotonin (5 Hydroxytryptamine)IBA 11/2021
1	Streptozocin (Streptozotocin)FDA Link 11/2021
1	Adrenergic Agents (Adrenergic Drugs)IBA 11/2021
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2021
1	Dopamine Receptors (Dopamine Receptor)IBA 11/2021
1	Indicators and Reagents (Reagents)IBA 06/2021
1	Valine (L-Valine)FDA Link 01/2021
1	Amino Acids FDA Link 01/2021
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2021
1	protease-activated receptor 4IBA 11/2020
1	Thrombin FDA Link 11/2020
1	HeterochromatinIBA 01/2020
1	Small Interfering RNA (siRNA)IBA 01/2020
1	melanopsinIBA 01/2020
1	ChromatinIBA 01/2020
1	EuchromatinIBA 01/2020
1	benzothiopheneIBA 01/2019
1	Selective Estrogen Receptor Modulators (SERM)IBA 01/2019

Therapy/Procedure

21	Therapeutics 11/2021 - 06/2006
2	Injections 01/2022 - 01/2018
2	Oral Administration 12/2014 - 05/2002
1	Lasers (Laser) 01/2019